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Ubiquinol is the active, antioxidant form of coenzyme Q10, naturally produced in the body. It plays a vital role in generating energy in cells and helps protect them from free radical damage. As we age, our body’s ability to produce Ubiquinol declines,[1,2] which may affect energy levels and overall wellbeing. Ubiquinol is especially important for supporting energy production in organs like the heart, liver and muscles. Supplementing with Ubiquinol may help maintain these levels and support your energy and vitality, particularly as you age.
Ubiquinol is the active form of CoQ10 that your body uses directly. Ubiquinone is the oxidised form that must be converted into Ubiquinol before the body can use it. As we age, this conversion becomes less efficient.[1,2] Kaneka Ubiquinol™ is 3-8 times more absorbable than ubiquinone,[3-6] making it a more efficient supplement to support energy and antioxidant protection.
Ubiquinol is suitable for a range of conditions and contributes to overall health and wellbeing for adults over 30 years of age. Supported by 100+ clinical studies over 45+ years of research, Kaneka Ubiquinol™ is an evidence-based supplement recommended by healthcare practitioners to support multiple health conditions such as: a healthy heart and vascular system,[7,8] healthy LDL cholesterol levels in healthy people,[7,9] healthy male and female fertility,[10-14] cognitive function,[15,16] energy production and fatigue,[17,18] migraines,[19] inflammation[20,21] and optimal wellbeing.[22,23]
Ubiquinol supports cellular energy production,[24,25] helps relieve fatigue,[17,18] maintains cardiovascular health,[7-9] supports muscle[26,27] and cognitive function,[15,16] and provides antioxidant protection[28]. It may also help maintain healthy cholesterol levels,[7,9] and support fertility in both men and women.[10/14] Ubiquinol contributes to general wellbeing and vitality,[22,23] especially as we age[29].
From age 20 onwards, natural Ubiquinol levels begin to decline.[1,2] Adults over 30 may benefit from supplementing to support ongoing energy and wellbeing. Most people feel a difference within 1-2 weeks of regular use.[30] This may vary depending on your age, lifestyle and health condition. Consult your healthcare professional for personalised advice.
Ubiquinol is found in some foods like red meat, chicken and sardines, but in small amounts. To get 100 mg of Ubiquinol from food alone, you’d need to eat one of the following:[31]
- 20 steaks
- 34 chicken breasts
- 60 avocados
- 1.6 kg of peanuts
- 50 cups of spinach
- 120 cans of sardines
Yes, Ubiquinol supports energy production in the muscles[26,27] and helps reduce fatigue.[17,18] Research shows it may assist with exercise recovery by reducing inflammation and oxidative stress.[20,21,28] Athletes and active individuals may experience improved endurance and performance when taking Ubiquinol.[32-34] Always consult a healthcare practitioner for advice specific to your needs.
If you take prescription medications, such as warfarin, consult your healthcare practitioner before starting Ubiquinol. Ubiquinol is generally well-tolerated, but there may be medications or health situations where Ubiquinol may not be warranted. Some medications may reduce CoQ10 levels and supplementing with Ubiquinol may help restore them. Seek professional advice to ensures it’s right for your individual needs.
Common dosages range from 100 mg to 300 mg daily, depending on your age, lifestyle and health needs. Your healthcare practitioner can recommend the best dose for you. Ubiquinol supplements are available in various strengths to suit your personal health goals.
Kaneka Ubiquinol™ is the only patented, stabilised form of Ubiquinol made via a unique yeast fermentation process. It is bioidentical to the Ubiquinol naturally produced in your body, clinically researched, and trusted by healthcare professionals. Look for the Kaneka Seal of Quality to ensure purity and effectiveness in your product.
- Kalén A, et al. Age-related changes in the lipid compositions of rat and human tissues. Lipids 1989;24(7):579-584.
- Wada H, et al. Redox status of coenzyme Q10 is associated with chronological age. JAGS. 2007;55:1141-1142.
- Alf D, et al. Ubiquinol supplementation enhances peak power production in trained athletes: a double-blind, placebo controlled study. J Internat Soc Sports Nutr 2013;10(24):1-8.
- Zhang Y, et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct 2018;9(11):5653-5659.
- Hosoe K, et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol 2007;47:19-28.
- Ikematsu H, et al. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol 2006;44:212-218.
- Rabanal-Ruiz Y, et al. The use of coenzyme Q10 in cardiovascular diseases. Antioxidants (Basel) 2021;10(5):755.
- Kawashima C, et al. Ubiquinol improves endothelial function in patients with heart failure with reduced ejection fraction: A single-center, randomized double-blind placebo-controlled crossover pilot study. Am J Cardiovasc Drugs 2020;20(4):363-372.
- Sabbatinelli J, et al. Ubiquinol ameliorates endothelial dysfunction in subjects with mild-to-moderate dyslipidemia: A randomized clinical trial. Nutrients 2020;12(4):1098.
- Derbyshire E (2024). CoQ10 Ubiquinol: The surfacing of science and role in female and male fertility. A narrative review. 10.20944/preprints202407.0879.v1.
- Wu CC, et al. Examining the effects of nutrient supplementation on metabolic pathways via mitochondrial ferredoxin in aging ovaries. Nutrients 2024;16(10):1470.
- Thakur AS, et al. Effect of Ubiquinol on serum reproductive hormones of amenorrhic patients. Indian J Clin Biochem 2016;31(3):342-348.
- Alahmar AT. The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia. Clin Exp Reprod Med 2019;46(3):112-118.
- Thakur AS, et al. Effect of ubiquinol therapy on sperm parameters and serum testosterone levels in oligoasthenozoospermic infertile men. J Clin Diagn Res 2015;9(9):BC01-03.
- Kinoshita T, et al. The effects of ubiquinol (reduced form of coenzyme Q10) on memory, attentiveness, and work processing ability in healthy middled-aged and elderly residents – A randomized, double-blind, placebo-controlled trial. Jpn Pharmacol Ther 2021;49:1739-1747.
- Fernández-Portero C, et al. Coenzyme Q10 levels associated with cognitive functioning and executive function in older adults. J Gerontol A Biol Sci Med Sci 2023;78(1):1-8.
- Mizuno K, et al. Ubiquinol-10 intake is effective in relieving mild fatigue in healthy individuals. Nutrients 2020;12(6):1640.
- Fukuda S, et al. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors 2016;42(4):431-440.
- Nattagh-Eshtivani E, et al. The role of nutrients in the pathogenesis and treatment of migraine headaches: Review. Biomed Pharmacother 2018;102:317-325.
- Fischer A, et al. Coenzyme Q10 redox state predicts the concentration of c-reactive protein in a large caucasian cohort. Biofactors 2016;42(3):268-276.
- Suomalainen A, Nunnari J. Mitochondria at the crossroads of health and disease. Cell 2024;187(11):2601-2627.
- Cirilli I, et al. Role of coenzyme Q10 in health and disease: An update on the last 10 years (2010–2020). Antioxidants 2021;10:1325.
- San-Millán I. The key role of mitochondrial function in health and disease. Antioxidants (Basel) 2023;12(4):782.
- Guaras A, et al. The CoQH2/CoQ ratio serves as a sensor of respiratory chain efficiency. Cell Reports 2016;15:197-209.
- Tian G, et al. Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice. Antioxid Redox Signal 2014;20(16):2606-2620.
- Suzuki Y, et al. Short-term ubiquinol-10 supplementation alleviates tissue damage in muscle and fatigue caused by strenuous exercise in male distance runners. Int J Vitam Nutr Res 2021;91(3-4):261-270.
- Diaz-Castro J, et al. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise. Food Funct 2020;11(9):7523-7531.
- Hernández-Camacho JD, et al. Coenzyme Q10 supplementation in aging and disease. Front Physiol 2018;9:44.
- Shoko D, et al. The effect of the reduced form of coenzyme Q10 (Ubiquinol, Kaneka QH™) on QoL improvement in the elderly. J Clin Therap Med 2008;24:233-238.
- Mantle D, Dybring A. Bioavailability of coenzyme Q10: An overview of the absorption process and subsequent metabolism. Antioxidants (Basel) 2020;9(5):386.
- Schulman, R. et al. (2023) Ubiquinol content in common foods, Ubiquinol. Available at: https://ubiquinol.org/foods-with-ubiquinol
- Kunching S, et al. The effects of ubiquinol supplementation on clinical parameters and physical performance of trained men. Songklanakarin J Sci Technol 2022;44(1):231-235.
- Alf D, et al. Ubiquinol supplementation enhances peak power production in trained athletes: a double-blind, placebo controlled study. J Internat Soc Sports Nutr 2013;10(24):1-8.
- Sarmiento A, et al. Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial. Biofactors 2016;42(6):612-622.
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