How to Combat Fatigue with Mitochondrial Energy

How to Combat Fatigue with Mitochondrial Energy

Jul 2022
Recent Article

Does your Mitochondrial Health Measure Up?

Fatigue seems to be a common complaint. When a cup (or three) of coffee feels like the only way to get through the day, it might be worth taking a look at your mitochondrial health, as this plays a powerful role in energy production –  and is worth considering if you’re experiencing fatigue.

What is fatigue?

Fatigue is often described as lack of energy, mental or physical tiredness, decreased endurance and the need for a longer recovery period after physical activity.[1] It can be caused by physical or psychological conditions, or a combination of both. However, fatigue is often related to other factors, such as lifestyle choices, poor sleep or nutritional deficiencies.[2]

Meet your mitochondria – The powerhouse of cells

The mitochondria is often referred to as the powerhouse of the cell, enabling us to perform our body’s daily functions such as breathing, our heartbeat, speaking, as well as other activities, with energy and vigour.

The mitochondria are cell organelles whose key role is to generate most of the chemical energy that our body needs to keep functioning.[3] Producing energy is so important that each cell contains between 1000 to 2500 mitochondria.[4] These organelles act like a second digestive system, transforming the food we eat into energy that cells in our bodies use, known as ATP.[5] Therefore, most cellular functions, from respiration to metabolism and immune defense, need the right supply of ATP to meet the energy demands for all these processes.[6]

How can we combat fatigue?


We may think that exercising will make us feel more tired and therefore we avoid it when our energy levels are low. However, the reality is that moving more may increase our energy levels. This is due to cellular-level changes that take place when we exercise.

A study found that high-intensity interval training brings the biggest benefits at the cellular level to increase mitochondrial capacity by 49% in young individuals and by 69% in older people.[7]. Mitochondria are the energy source of our body, so having more of them increases our body’s energy supply.[8]


Dehydration occurs when the water content of the body is low, limiting its ability to carry out normal organ functions and activity which in turn may affect our health, mood and performance. However, if we drink enough water, it prevents symptoms such as tiredness and weakness.[9]


It is remarkable how small changes in our diets and eating habits can increase our energy levels, focus and performance.  Not consuming enough wholegrains, lean meats, dairy, fruit and vegetables can result in feeling fatigued.[10]

However, the solution does not rely on increasing our caffeine intake in foods or beverages,[11] but rather maintaining a balanced diet that includes a variety of unrefined carbohydrates, proteins and fats, as well as a  large serving of green vegetables and unsaturated oils with health benefits.

Since we start the energy production process through food, it is worth supporting our mitochondria with the right nutrients as these organelles are especially affected by nutrient deficiencies, environmental toxins, and oxidative damage. Although many nutrients are necessary for ATP production, ubiquinol, the active form of coenzyme Q10, plays an important role in this process.[4].

Ubiquinol, a lipid antioxidant, can be found throughout the body, especially in mitochondria. However, our natural ubiquinol levels start decreasing from the age of 30. While a healthy diet, hydration and exercise are all important considerations, in some cases, supplementation might be needed to help these powerhouses produce the necessary energy that our body needs to function at its optimal level.[6]

Taking a ubiquinol supplement may be an efficient way to help restore healthy levels of ubiquinol in the body and support optimal energy levels.[1]

 Always read the label. Use only as directed. If symptoms persist consult your healthcare professional.

[1] Filler K, et al. Association of Mitochondrial Dysfunction and Fatigue: A Review of the Literature. BBA clinical 2014;1:12-23. 
[2] Health Direct 2021. Fatigue. [online] Available at: [Accessed 18 October 2021]
[3] Genome 2021. Mitochondria. [online] Available at: [Accessed 18 October 2021]
[4] Pizzorno J. (2014). Mitochondria-Fundamental to Life and Health. Integrative medicine (Encinitas, Calif.), 13(2), 815.
[5] British Society for Cell Biology 2021. Mitochondrion – much more than an energy converter [online] Available at: [Accessed 18 October 2021]
[6] Saini R. Coenzyme Q10: The essential nutrient. J Pharma Bioallied Sci 2011;3(3):466-467.
[7] Cell Press. (2017, March 7). How exercise — interval training in particular — helps your mitochondria stave off old age. ScienceDaily. Retrieved October 18, 2021 from
[8] Harvard Health. 2021. Does exercise really boost energy levels? – Harvard Health. [online] Available at: [Accessed 18 October 2021].
[9] Better Health Channel 2021. Water – a vital nutrient. [online] Available at: [Accessed 18 October 2021].
[10] Better Health Channel 2021. Fatigue fighting tips. [online] Available at: [Accessed 18 October 2021].
[11] Sports Dietitians Australia (SDA) 2021. Fighting Fatigue. [online] Available at: [Accessed 18 October 2021].

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